The percentages of CD4+CD25+Foxp3+ Treg cells collected from the splenic, thymic and peripheral blood cells, as well as the percentages of IL-10+ Bregs collected from the splenic and thymic cells increased significantly in the LZ–SMS-treated SLE mice (P < 0.05) compared with the untreated PBS group. Here, CD4 is linked to systemic lupus erythematosus.