BTG3 and systemic lupus erythematosus: Although the plasma concentrations of ANA and anti-ds-DNA antibodies in the moderate and severe SLE mice treated with LZ–SMS were significantly higher than those of the Balb/c control mice, the plasma concentrations of anti-ds-DNA in the moderate (P < 0.001) and severe SLE mice (P = 0.05) were both significantly lower than those of the PBS-treated mice.