MTOR and neoplasm: The elevated mTOR signaling was surprising in that sunitinib- and axitinib-treated tumors become hypoxic in response to collapse of the tumor vasculature (Pàez-Ribes et al., 2009, Sennino et al., 2012), and observations presented below), and mTOR is typically downregulated in hypoxic conditions (Brugarolas et al., 2004).