MTOR and cancer: The RIP1Tag2 model has also been used to investigate other cancer hallmarks, including resistance to apoptosis and induction of invasiveness, which are variously regulated by signaling from receptor tyrosine kinases, including EGFR, IGFR, IR, and ALK (Chun et al., 2010, Nolan-Stevaux et al., 2010, Ulanet et al., 2010); these signals converge in part on the mTOR kinase, which orchestrates a broad program affecting cell survival and metabolism (Laplante and Sabatini, 2012, Cornu et al., 2013).