Previous studies have shown that VEGF‐B gene transfer resulted in prevention of the angiotensin II‐induced diastolic dysfunction associated with induction of the Akt pathway (Serpi et al., 2011), while VEGF blockade promotes the transition from compensatory cardiac hypertrophy to failure in response to pressure overload (Izumiya et al., 2006). This evidence concerns the gene AKT1 and cardiac hypertrophy.