Importantly, as a novel regulator of metabolic homeostasis (Lee et al., 2008; Zhou et al., 2011; Wu et al., 2014), the proposed XBP1 regulation of VEGF also broadens our knowledge on the pathologies of metabolic syndrome and sheds light on the intervention of diabetes mellitus and obesity‐related metabolic diseases. This evidence concerns the gene XBP1 and Other metabolic disease.