Young pre-obese homozygous R299Q γ2 mice exhibited small reductions in plasma leptin compared to WT, with comparable adiponectin (Table S1), but by 40 weeks displayed hyperleptinemia and hypoadiponectinemia (the latter with reduced WAT expression; Figure S1M), consistent with obesity. Here, ADIPOQ is linked to obesity due to melanocortin 4 receptor deficiency.