NF1 and neuroblastoma: This finding stands in marked contrast to the inability of the same zebrafish line expressing the same level of GRD to rescue overgrowth of the SCG in normal development, indicating that even though a novel mechanism is responsible for restriction of PSNS neuron growth during normal embryogenesis, NF1 still acts as a classical GAP protein to suppress RAS-MAPK signaling for the suppression of neuroblastoma.