NF1 and neuroblastoma: As in many other pediatric cancers, resequencing studies have documented a very low frequency of somatic mutations in neuroblastoma (Cheung et al., 2012; Molenaar et al., 2012; Pugh et al., 2013), including ALK (~9.2% of cases), PTPN11 (~2.9%), ATRX (~2.5%) and NF1 (~1%).