The same relationship likely applies to melanoma cell lines as well, since most of these tumors harbor activating mutations in the RAS-MAPK pathway, including BRAF V600E and NRAS Q61L/R, as well as the loss of NF1 in a subset of cases (Cancer Genome Atlas Network, 2015; Hodis et al., 2012). This evidence concerns the gene NF1 and melanoma.