Genomic aberrations that inactivate the NF1 tumor suppressor gene, including loss-of-function mutations and deletions, as well as decreased expression levels of the gene, have been identified in 6% of primary neuroblastomas and are predictive of a poor outcome (Hölzel et al., 2010), suggesting an important role for NF1 loss in neuroblastoma tumorigenesis. Here, NF1 is linked to neuroblastoma.