ISPD was a reasonable candidate since, as a putative cytosolic nucleotidyltransferase (Vuillaumier-Barrot et al., 2012), it is mutated in a subset of CMD and LGMD patients (Willer et al., 2012; Cirak et al., 2013), and bacterial homologs participate in the synthesis of CDP activated alcohols (Baur et al., 2009; Richard et al., 2001). This evidence concerns the gene CRPPA and limb-girdle muscular dystrophy.