Melanoma differentiation associated gene 5 stimulation in HCAEC led to an up‐regulation of ICAM‐1 (Fig. 1C: polyIC 3.79 ± 0.85 2−∆∆Ctversus polyA 1.18 ± 0.13 2−∆∆Ct, P < 0.05, n = 3–4) and VCAM‐1 (Fig. 1D: polyIC 5.35 ± 1.23 2−∆∆Ctversus polyA 1.18 ± 0.28 2−∆∆Ct, P > 0.05, n = 3–5), two adhesion molecules associated with activated and dysfunctional ECs 19. The gene discussed is VCAM1; the disease is melanoma.