Other possible mechanisms of genetic association include modulation of an antisense GRM3 transcript (Buonaguro et al., 2015), or effects of genotype on mGlu3 which are limited to specific locations or developmental stages, as is the case for some other schizophrenia risk genes (Kleinman et al., 2011, Birnbaum et al., 2014, Paterson et al., 2014, Tao et al., 2014). Here, GRM3 is linked to schizophrenia.