In conclusion, the results presented here suggest that MSC restores lung vascular permeability, which might be associated with the protective effects of MSC on the adherens junction protein VE-cadherin and lung vascular endothelial cell apoptosis, reducing inflammation, and attenuating lung injury in LPS-induced ALI in rats in part by maintaining the HGF level in the injured lung. The gene discussed is HGF; the disease is acute respiratory distress syndrome.