Further, in common with two thirds of the genes that act downstream of gpa-12 (the targets of the G-clones, including hars-1, lars-1, rars-1 and tars-1), we found that nipi-3, which encodes a homolog of Tribbles required for the response to infection [3], is also required for the expression of nlp-29 upon osmotic stress. This evidence concerns the gene HARS1 and infection.