Our proteomic analysis revealed that several ribosomal proteins co-immunoprecipitate with HEY1, including seven of the ribosomal proteins shown to activate p53 by inhibiting MDM2 function, one of which is RPL11, an essential player during p53 induction in response to ribosomal stress with increasing relevance in tumour suppression [31,51,52]. This evidence concerns the gene HEY1 and neoplasm.