In agreement with the negative regulation of TGF-β signaling by PARP1, prostate tumors developing in a mouse carrying complete loss of function mutation of PARP1 revealed enhanced epithelial-mesenchymal transition caused by enhanced TGF-β signaling in the prostate carcinoma cells (26), which corroborates our original findings whereby PARP1 impacted the mesenchymal transition of mammary epithelial cells (22). This evidence concerns the gene PARP1 and prostate carcinoma.