It is reported that 60% of the DLBCL specimens showed higher local vascular endothelial growth factor (VEGF) expression, higher VEGF receptor (VEGFR) expression and correspondingly higher micro-vessel density [8], which provides a theoretical foundation for the use of anti-angiogenesis therapy in patients with DLBCL. The gene discussed is VEGFA; the disease is diffuse large B-cell lymphoma.