Additionally, inhibition of the MDM2-p53 interaction induced cyclin D1 and cyclin E expression (Figure 2, Figure 3A, and Figure S1), which is consistent with published data showing that expression of MDM2-A resulted in induction of cyclin D1 and cyclin E in Hodgkin's lymphoma cells [17]. The gene discussed is CCND1; the disease is Hodgkins lymphoma.