SLC7A11 and tuberculosis: To determine the potential role of xCT in the pathogenesis of TB, we compared outcomes of Mtb infection between wild type (WT) and xCT Knock out mice (xCT−/−) [9]. Compared to the WT mice, xCT−/− mice had a significant reduction in bacteria burden in the lung at d15 and d30 p.i. (Figure 3A), indicating that disruption of xCT enhanced bacterial clearance.