TNF and osteosarcoma: Using ATP levels to monitor survival, cells from four tumors (98Sc, 493H, 494H and 1029H) were killed by levels of SM-164 or GDC-0152 that are likely to be physiologically achievable, coupled with concentrations of TNFα that were similar to or up to 100-fold higher than those detected in the blood of osteosarcoma patients [53].