The relatively low percentage of chondrosarcomas and well-differentiated liposarcomas harboring activated TAZ and YAP is due to the observation (discussed further below) that the activated oncoproteins are relatively absent in the lower grade examples of these sarcomas (grade 1/2 chondrosarcomas and well-differentiated liposarcoma), but present at higher frequencies in higher grade examples (grade 3 chondrosarcoma and dedifferentiated liposarcoma). The gene discussed is WWTR1; the disease is sarcoma.