EPAS1 and nonpapillary renal cell carcinoma: Developing study designs that focus on stratified samples (by VHL and/or HIF1A/HIF2A status) along with multiple samples from tumors and a multi-domain approach (such as proteotranscriptomic) is necessary to more clearly define the molecular pathogenesis of ccRCC and identify new therapeutic targets that are required for metastatic ccRCC.