In summary, effective human cell intraperitoneal transplantation and subsequent HIV-1 LAI intraperitoneal infection were observed in all BRGS mice in groups A and B. HIV-1 infection in this experimental model leads to a decrease in human cells over time, especially human CD4+ T cells, thereby reproducing the dynamics of CD4+ T cell depletion observed in human HIV infection. This evidence concerns the gene CD4 and HIV infectious disease.