PRRT2 and Insulin resistance: This induction of insulin resistance is associated with an increase in total membrane-associated PKC activity, translocation of the protein kinase C-β (PKC-β) and δ from the cytosol to the cell membrane, an increase in diacylglycerol (DAG) mass and a 70% decrease in the abundance of IκB-α, an inhibitor of NF-κB [73].