Besides, diabetes is characterized by hyperglycemia and hyperlipidemia, two biochemical features associated with inhibition of endothelial nitric oxide synthase (eNOS), leading to diminished NO production, increased formation of reactive oxygen species (ROS) and formation of free radicals, lower efficacy of antioxidant systems , that are important agents in the development of diabetic complication [27,28]. Here, NOS3 is linked to diabetes mellitus.