While “Obese/Metabolic NAFLD” is associated with NAFLD and features of the MetS and an increased risk of type 2 diabetes and cardiovascular disease, NAFLD caused by I148M variant in PNPLA3 and the E167K variant in TM6SF2 is not accompanied by insulin resistance. Here, PNPLA3 is linked to metabolic dysfunction-associated steatotic liver disease.