APAF1 and cancer: Validated miR-155 target genes are present in multiple pathways associated with cancer and cancer progression, including EMT (SMAD5), proliferation (SOCS1, INPP5D, and CSF1R), block of differentiation (SPI1, CEBPB), and apoptosis (CASP3, FADD, APAF1, and FOXO3A) [359,360,361,362,363,364,365,366,367].