miR-375 is a tumor suppressor miRNA that has been described in different kind of cancers, where it targets genes related to proliferation and apoptosis (JAK2, PDK1, 14-3-3ζ, IGF1R, KLF4, KLF5, survivin, ERBB2, PIK3CA, MTDH, YAP1, CIP2A/KIAA1524, MTDH, and BCL2) [401,402,403,404,405,406,407,408,409,410,411,412,413,414] as well as metastasis (IGF1R, CLDN1, CIP2A/KIAA1524, and BCL2) [404,412,414,415] and mediates resistance to therapy (IGF1R, TP53, and PHLPP1) [416,417,418]. The gene discussed is BCL2; the disease is cancer.