PTEN and cancer: Other pathways regulated by miR-221/-222 include apoptosis and metastasis via PTEN [389], IRF2, SOCS3 [393], BBC3 [399], SEMA3B [392], HECTD2, RAB1A [396], ADAM17, ITGB4, STAT5A [398], and Ecm29/KIAA0368 [400]; in resistance to chemotherapy in some type of cancers through PTEN [389] and β-catenin/CTNNB1 [397] regulation.