MTHFR and metabolic dysfunction-associated steatotic liver disease: Similarly, the meta-analysis of A1298C polymorphism based on 11 case-control studies in Caucasian population provided the evidence that a significantly increased NAFLD risk was observed under allele model (C vs A), homozygote model (C/C vs A/A), dominant model (A/C+ C/C vs A/C) and recessive model (C/C vs A/A+A/C), but not heterozygote model (A/C vs A/A), suggesting that C/C genotype of MTHFR A1298C polymorphism might be linked to the susceptibility to NAFLD in Caucasian population.