It was also demonstrated that despite their contrasting IFN-sensitive replication phenotypes, infection of suckling mice with either EW-RV or RRV results in similar induction of several IFN-stimulated genes (ISGs) in the small intestine at 16 hours post infection (hpi), confirming prior observations and indicating that RRV replication is uniquely sensitive to one or more of these antiviral effectors [6]. Here, IFNA1 is linked to infection.