In what regards susceptibility to the ulcerative form of BU disease, the rs2241880 (T300A) SNP in the ATG16L1 gene was found to significantly protect patients from presenting the ulcer phenotype when a recessive genetic model was applied [OR, 0.35 (95% CI, 0.13–0.90); P = 0.02] (Table 3). Here, ATG16L1 is linked to ulcer disease.