From basic science new therapeutic targets were shown including the TWEAK–Fn14–NF‐κB–MuRF1– myosin heavy chain protein degradation cascade and the neutralization of tumour‐derived parathyroid‐hormone‐related protein, as well as the influence and the role of the gut microbiota in the therapeutic management of cancer and associated cachexia. Here, TNFRSF12A is linked to cancer.