The geometric mean of ISCs (IgA + IgG + IgM) /106 PBMC in those with acute sinusitis was 8689 (95%CI 3952–17020), those with acute tonsillitis 9532 (5695–16554), and in healthy controls 1135 (887–1420) (Fig 2). This evidence concerns the gene CD40LG and Recurrent tonsillitis.