Additionally, significant prognostic factors included age, differentiation, vascular tumor emboli, nervous invasion, tumor location, tumor size, Borrmann type, TNM stage, family history of gastric cancer, family history of other cancers, p21 overexpression, Neu/Her-2 overexpression, and EGFR overexpression (Table 4). Here, ERBB2 is linked to vascular neoplasm.