Additionally, significant prognostic factors included age, differentiation, vascular tumor emboli, nervous invasion, tumor location, tumor size, Borrmann type, TNM stage, family history of gastric cancer, family history of other cancers, p21 overexpression, Neu/Her-2 overexpression, and EGFR overexpression (Table 4). The gene discussed is ERBB2; the disease is gastric cancer.