Based on the crucial roles of CXCR4 and CXCR5 in CLL cells trafficking within the lymph nodes [16, 32, 50] and given that CXCR4 is associated with poor clinical outcome in CLL patients [10, 58, 59], we explored the clinical relevance of BCR-PKD-CXCR4/CXCR5 signaling pathway. The gene discussed is CXCR5; the disease is B-cell chronic lymphocytic leukemia.