Western blotting analysis of 6 CLL cell lysates using anti-PKD1/2 (recognizing both PKD1 and PKD2), anti-PKD2 and anti-PKD3 antibodies confirmed variable expression of PKD2 and PKD3 proteins and absence of detectable PKD1 as compared to 293T cells expressing the 3 isoforms [42] (Figure 3B). Here, PKD2 is linked to B-cell chronic lymphocytic leukemia.