Evaluation of target proteins in tumor lysates showed that BMS-754807 treatment decreased levels of the activated form of IGF-1R/IR and downstream effectors AKT and ERK, and induced levels of the apoptosis related proteins cleaved caspase-3 and cleaved PARP-1, indicating that the BMS-754807 therapy is indeed managing to sufficiently affect these targets within the local tumor model. The gene discussed is AKT1; the disease is neoplasm.