Furthermore, we found that S100A4 overexpression was associated with the presence of lymphovascular invasion (Table 1) and decreased overall survival among patients with lung adenocarcinoma (Figure 3C; median survival: 29.5 versus 70 months, hazard ratio 2.62, 95% confidence interval 1.133 to 6.035, P = 0.0243). This evidence concerns the gene S100A4 and lung adenocarcinoma.