In addition, the results of our and others' studies revealed that abdominal or intracerebroventricular injection (i.c.v.)of M35, a galanin antagonist, significantly increased insulin resistance and inhibited the glucose transporter 4 (GLUT4) translocation from intracellular membrane compartments to cell surfaces in skeletal muscle and fat tissue of rats [7–12]. This evidence concerns the gene GAL and Insulin resistance.