In summary, the current results in the study suggest that activation of central GalR1 facilitates adiponectin release, glucose infusion rates in the hyperinsulinemic-euglycemic clamp test, GLUT4 mRNA expression, and GLUT4 translocation from intracellular membrane compartments to cell surfaces but inhibits the CRP release to benefit insulin sensitivity in adipose cells of type 2 diabetic rats. This evidence concerns the gene SLC2A4 and type 2 diabetes mellitus.