BID and lung carcinoma: In addition, Park et al. [44] found that treatment of human lung carcinoma cell line with SSe resulted in an early modulation of the extrinsic apoptotic pathway, represented by an upregulation in the expression of Fas and death receptor, which was coupled with decreased expression of pro-Bid suggesting that truncated Bid might have served to connect both extrinsic and intrinsic apoptotic pathways.