Of particular note, miR34a overexpression could partially block the effects of LMVs on AML cell proliferation, migration, and proliferation, although it was able to significantly elevate caspase-3 activity and decrease Tim-3 expression in AML cells; these data suggests that other miRs and associated mechanisms may also participate in LMVs-induced effects. This evidence concerns the gene CASP3 and acute myeloid leukemia.