Increased lipolysis during lactation in HF rats may be associated with an observed decrease in the concentration of plasma obestatin on the 14th day of lactation and then its significant increase at the end of lactation (21st day) although recent studies by Pruszyńska-Oszmałek et al. [29] have suggested that obestatin may inhibit lipogenesis. The gene discussed is GHRL; the disease is hydrops fetalis.