It is also well known that other histological types and atypia grades of gastric cancer have higher potential for SM invasion and lateral spread than LG-tub1 [9, 12] and that the larger in size D-EGC lesion with gastric mucin phenotype becomes the more undifferentiated types of cancer components with gastric mucin phenotype increase [18, 19]. The gene discussed is MUC5AC; the disease is gastric cancer.