To investigate whether DCC variants were associated with the clinical features of patients with BC, we further analyzed the distributions of DCC variants with respect to a series of clinicopathological parameters including tumor size; axillary lymph node (LN) metastasis; and estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki67 index statuses. This evidence concerns the gene ESR1 and breast cancer.