HNF4A and posterior cortical atrophy: Given the high structural similarity between cvTBLR1 and Ebi(ΔF), the overexpression of cvTBLR1 in AI PCa cells suggest that cvTBLR1 may function as a dominant negative form to inhibit β-catenin degradation and thus induce cytoplasmic accumulation of β-catenin and TCF/LEF activity.