RB1 and neoplasm: Also for tumor T7, from a non-familial unilateral patient, both high-level amplification of MYCN and RB1 inactivation was observed (20 nucleotides frameshift insertion in exon 1; NM_000321:c.25ins20:pT9fs), although RB1 inactivation was missed by WES because of low exon 1 coverage.