PCSK9 and familial hyperaldosteronism: The specific gain-of-function PCSK9 mutation (p.Asp374Tyr), a common mutation in lipoprotein lipase gene (p.Asn291Ser),11ACE DD genotype12 and genetic polymorphisms, for example, presence of E2 and E4 alleles in apolipoprotein E,13 are known to increase the CHD risk in patients with FH, while some PCSK9 loss-of-function variants and APOB gene mutations are associated with a lower risk.