LDLR and atherosclerosis: Individuals with FH have higher carotid IMT and femoral IMT compared with people with normal lipid levels or other types of inherited hypercholesterolaemia such as familial combined hypercholesterolaemia.22 Also, among patients with FH, individuals carrying LDLR null alleles have higher cIMT measurements than those with LDLR defective alleles.23 The cIMT in patients with FH might help to differentiate patients with a severe form of FH with more advanced atherosclerosis who are at higher risk of CHD.