Interestingly, the content of ANP has been reported to increase in reactive astrocytes 3 days after injury in the white matter (WM) from autopsied human brain specimens after brain infarction and upregulation of the ANP/cGMP pathway (ANP is a vasorelaxant) may contribute to an increase in BF in response to the BF reduction in the infarcted area [24]. This evidence concerns the gene NPPA and brain infarction.