However, in a quantitative meta-analysis of 20 studies (4285 patients), Tan et al. found that the overall sensitivity and specificity of CEA for detecting CRC relapse were 63.9 % (95 % CI 0.613–0.665) and 90.4 % (95 % CI 0.892–0.914), respectively [57]. The gene discussed is CEACAM5; the disease is colorectal carcinoma.