To determine whether LY500307 has an effect on ERβ-mediated rapid extra-nuclear signaling, GBM cells were treated with LY500307 for short periods of time (5, 15, and 30 min) and the phosphorylation status of p38MAPK, JNK, ERK1/2 and Akt was examined. Here, MAPK8 is linked to glioblastoma.