Hepcidin, a 25-aa peptide hormone engaged in the control of body iron homeostasis, which is encoded by a gene located on chromosome 19q13, 13.8 kbp upstream from IFNL3 sequence, was suggested to have a pivotal role in the development of iron overload syndrome in CHC [14, 18]. Here, IFNL3 is linked to cryohydrocytosis.