For other proteins, the frequency of positive/negative IHC staining did not vary according to diabetes, NSAID use, parity, OC use, and PTEN status, and none of the IHC proteins for any insulin/IGF or sex hormone axis components differed in comparisons of BMI, smoking status, age at menarche, ever versus never pregnant, and NSAID type (Supplementary Tables 3 and 4). This evidence concerns the gene INS and diabetes mellitus.