Among postmenopausal participants, we observed higher pIGF1R/pIR levels in endometrial tissues from diabetic versus non-diabetic women, which may reflect the impact of high circulating insulin levels on activation of these cancer-related receptors, and regular use versus no use of NSAIDs was associated with a higher expression of PR but not ER, which could be associated with a lower endometrial cancer risk. This evidence concerns the gene ESR1 and endometrial cancer.