There were significant differences in protein levels for several of the risk factor comparisons; for example, postmenopausal participants with diabetes had a higher frequency of positive pIGF1R/pIR endometrial IHC staining as compared to non-diabetics, respectively [pIGF1R/pIR glandular cytoplasmic staining, 6/7 (86 %) positive vs. 5/18 (28 %) positive, p value = 0.02] (Table 2; Fig. 1a, b). The gene discussed is PIR; the disease is diabetes mellitus.