To examine whether inhibition of EZH2 could sensitize synovial sarcoma cells to chemotherapeutic drugs in vitro, the Aska-SS and SYO-1 cells lines were treated with increasing concentrations of EPZ005687 and etoposide, topotecan, or doxorubicin over 14 days, and IC50s were determined by the MTT assay. Here, EZH2 is linked to synovial sarcoma.