Many forms of systemic inflammation, including sepsis, are associated with proteinuria (Drumheller et al., 2012; Emara et al., 2013; Schreiber et al., 2012) with high levels of pro-inflammatory cytokines such as IL-1, IL-6 and TNFα (Hotoura et al., 2011; Makhija et al., 2005; Martin et al., 1994), and some cases of NS have been shown to be responsive to TNFα blockade (Raveh et al., 2004). The gene discussed is TNF; the disease is Sepsis.