GUCY2C and inflammatory bowel disease: A study by Brenna Ø et al. revealed that GC-C, Gn and Ugn, as well as several downstream mediators of the GC-C signaling pathway, were all significantly downregulated in both the inflamed colonic mucosa of IBD patients and in rats with 2,4,6-trinitrobenzene sulfonic acid (TNBS) colitis10.