In addition, inflammatory infiltrates are highly prevalent within mesenchymal GBM.27 As reported previously, innate immune cells rely on the CD95/CD95L system to be recruited to the central nervous system after injury.33 And lately, innate immunity has been linked to efficient reprogramming in the induction of pluripotency.34 It is thus possible that a signal mediated by CD95L-bearing immune cells can contribute to the establishment of an aggressive tumor phenotype. This evidence concerns the gene FAS and glioblastoma.